Merhaba Misafir

Plasma amino-terminal propeptide of C-type natriuretic peptide concentration in normal-weight and obese children


Objective: In studies on the relationship between amino-terminal propeptide of C-type natriuretic peptide (NT-proCNP) concentration and height velocity in children, CNP has been implicated as an emerging new growth marker during childhood. It has been reported that besides its well-studied role in growth, plasma CNP levels are reduced in overweight and/or obese adolescents, suggesting CNP as a potential biomarker in childhood obesity. The primary goal of this study was to test this hypothesis in a Turkish population. Methods: Consent was taken from 317 children [ages 0-18 (158 girls, 159 boys)] and their parents. All subjects were physically examined; anthropometric measurements were obtained. Body mass index was calculated. During routine blood work, 1 mL extra blood was taken. Plasma NT-proCNP concentration was measured by enzyme-linked immunosorbent assay. Results: Results confirmed the previously described relationship between plasma NT-proCNP concentration and growth velocity. Plasma NT-proCNP concentration showed a negative correlation with age, weight, and height in children. Gender was not a factor that alters the age-dependent plasma NT-proCNP concentration until puberty. Conclusion: Unlike previous reports, plasma NT-proCNP concentration of overweight/obese children was not significantly lower than that of children with normal weight in age groups analyzed in a Turkish population. Thus, it is too early to conclude that CNP is a potential biomarker in childhood obesity. Further studies are necessary to address this question.

Yayınlandığı Kaynak : Journal of Clinical Research in Pediatric Endocrinology
  • Yıl : 2017
  • DOI : 10.4274/jcrpe.4543
  • Cilt : 9
  • ISSN : 1308-5727
  • Sayı : 4
  • eISSN : 1308-5735
  • Sayfa Aralığı : 308-314
  • IO Kayıt No : 62422
  • Yayıncı : Türk Pediatrik Endokrinoloji ve Diyabet Derneği