Merhaba Misafir

Obesity and insulin resistance are significant predictors of serum leptin levels

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To the Editor; In the December 2016 issue of your journal, Fakor et al. (1) presented an original article entitled “The association between levels of maternal serum leptin in the third trimester and the occurrence of moderate preterm labor” in which the authors elucidated the possible role of leptin in the development of preterm labor in 30 moderate preterm delivering women. The authors demonstrated that low serum leptin levels may have a substantial predictive value for preterm birth before 34 weeks’ gestation by altering cytokine balance, cytotrophoblast and angiogenic activity, in the feto-placento-maternal unit. Although the authors presented and discussed their study results effectively in the context of previous studies, we believe that like any other study, there are some methodologic issues related to the present paper. In this context, from a methodologic point of view, we have several concerns including unmatched body mass index (BMI) values of study participants, and the presence of a probable insulin resistance (IR), which is associated with preterm birth and serum leptin levels.

Yayınlandığı Kaynak : Journal of the Turkish-German Gynecological Association
  • Yıl : 2017
  • DOI : 10.4274/jtgga.2017.0027
  • Cilt : 18
  • ISSN : 1309-0399
  • Sayı : 3
  • eISSN : 1309-0380
  • Sayfa Aralığı : 158-159
  • IO Kayıt No : 57135
  • Yayıncı : Turkish-German Gynecological Association